The excretion of bismuth has been studied chiefly in animals. The clinical excretion of most of the products used currently in the treatment of patients with syphilis has not been determined. Certain products used by foreign investigators in studies of clinical excretion are not used in this country, and some of them are trade-marked specialties of unknown or uncertain composition. We have recorded a total of fifty-six different products reported in the literature, and one investigator1 claims to have prepared twenty-four organic bismuthyl derivatives. There might be, therefore, a total of eighty products of bismuth which have been or may be offered to physicians for use in the treatment for syphilis. Most of these products have little or nothing original to offer and are superfluous. In view of these circumstances, it appeared desirable to undertake studies of typical representatives of bismuth products under clinical conditions.
All products of bismuth
HANZLIK PJ, MEHRTENS HG, MARSHALL DC, WATSON F, SPAULDING J. CLINICAL EXCRETION OF BISMUTH: BISMUTH METAL. Arch Derm Syphilol. 1930;22(3):483–495. doi:10.1001/archderm.1930.01440150109011
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