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October 1930


Author Affiliations


From the Laboratory of Dermatological Research, University of Pennsyl

Arch Derm Syphilol. 1930;22(4):624-626. doi:10.1001/archderm.1930.01440160022004

The following results were obtained during certain inquiries which were particularly directed at the elimination of readily identifiable substances which might serve as a means of investigating the morbid physiology of dermatoses. The sweat and urine of four patients (and the blood of one) receiving bismuth for syphilis were tested for the presence of this metal. While essentially negative, the results have a bearing on certain final conclusions that I shall have to make further along in these studies.

Each of the subjects was free from lesions of the skin and was at or near the end of a course of treatment with bismuth. Treatments were given once or twice weekly by injection into the muscle of the buttock, followed by massage. Various preparations of bismuth were used, but all contained 0.03 Gm. of the metal per dose; the total amount given in the current course of bismuth therapy is

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