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Article
October 1930

A NEW FORM OF THERAPY FOR PSORIASIS: A PRELIMINARY REPORT

Author Affiliations

LOS ANGELES

Arch Derm Syphilol. 1930;22(4):685-686. doi:10.1001/archderm.1930.01440160083011
Abstract

Fifteen patients with psoriasis were treated by intramuscular injections of a suspension of the patient's own finely ground psoriatic scales in alcohol. The quantity of the scales obtained varied according to the character of the lesions. When it was possible, approximately 0.2 Gm. of psoriatic scales to 20 cc. of pure alcohol was used. The dosage employed varied from 1 to 4 cc., the average dose being 1.5 cc. These doses were given at intervals of three or four days. There has been no untoward or destructive reaction from its use, either locally or generally. All patients have responded to this form of therapy,, but in varying degrees. In general, the objective changes that occur are common to all, but the period of time of reaction varies fairly widely in difierent cases. In effect, these objective changes have been the following: (1) a thinning of the scales, which become less adherent. (2) A gradual paling of the centers of the lesions. The smaller, nummular areas usually demonstrate a single pale center and the larger plaques demonstrate multiple, pale foci. These foci, spreading gradually to the periphery, manifest themselves as normal skin. (3) The last stage shows a

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