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Article
November 1930

CLINICAL EXCRETION OF BISMUTH: BISMUTH SODIUM TARTRATE

Author Affiliations

SAN FRANCISCO

From the Department of Pharmacology and the Neuropsychiatric Division of the Department of Medicine, Stanford University School of Medicine.

Arch Derm Syphilol. 1930;22(5):850-860. doi:10.1001/archderm.1930.01440170076009
Abstract

This paper presents the results on excretion of bismuth after injection of bismuth sodium tartrate, a water-soluble compound in aqueous medium, in the same way as those in previous papers on bismuth metal1 and on potassium bismuth tartrate and bismuth salicylate.2 The bismuth sodium tartrate marketed by Searle and Company of Chicago was used; this consisted of a 1.5 per cent solution of the bismuth compound in 25 per cent sucrose solution containing 4 per cent of benzyl alcohol, as a local anesthetic. The bismuth content was 73.8 per cent, by analysis. The product was injected intramuscularly in eleven confined and ambulatory patients, seven of whom had cerebrospinal syphilis, and four variable degrees of edema of circulatory or hepatic origin without syphilis. The latter patients served as the subjects in a study of the diuretic action of the product, described in a previous paper,3 which also contained

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