Considerable attention has been paid within recent years to derangement of calcium metabolism in the study of disease. The literature is replete with references to estimations of the serum calcium in various pathologic conditions, and from these studies it appears that there is a variation from the accepted normal level of from 9 to 12 mg. per hundred cubic centimeters of serum.
Lowered values for serum calcium have been found in cases of rickets, osteomalacia, infantile tetany and spasmophilia, in some cases of acute and chronic nephritis, in uremia, in some cases of diabetes, more particularly if accompanied by ketonuria, in eclampsia, in hematogenous jaundice and in some cases of sprue. High values have been observed in atheroma and hypertension, in arthritis and in acute gout (Stewart and Percival1). Brown and Roth2 found the serum calcium to be much increased in polycythemia vera. Klemperer3 observed abnormalities in
KLAUDER JV, BROWN H. EXPERIMENTAL STUDIES IN ECZEMAV. STUDIES OF THE POTASSIUM, TOTAL AND DIFFUSIBLE CALCIUM RATIOS IN THE BLOOD OF PATIENTS WITH DISEASES OF THE SKIN. Arch Derm Syphilol. 1930;22(5):877–892. doi:10.1001/archderm.1930.01440170103011