To establish a histologic diagnosis of any one of the many clinical forms of tuberculosis of the skin, the tubercle must be present. When the tubercle is absent, other fields of investigation, such as the bacteriologic, serologic and biologic, must be employed to arrive at a diagnosis. When the tubercle is present, these methods should be employed to substantiate the histologic diagnosis.
The tubercle in dermal pathology is different from that of general pathology. It is composed of a group or nest of epithelioid cells within a lymphatic space, no matter where the lymphatic vessel is located, whether it is in the cutis or the subcutis.
Giant cells, plasma cells or lymphocytes may be present, but are not essential to the structure of the tubercle. One or more giant cells may be within the tubercle or may be independent of it. The lymphocytes may surround the tubercles or may be
SATENSTEIN DL. TUBERCULOSIS OF THE SKIN: HISTOLOGIC CONSIDERATION. Arch Derm Syphilol. 1931;23(2):309–316. doi:https://doi.org/10.1001/archderm.1931.03880200099007
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