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February 1931


Arch Derm Syphilol. 1931;23(2):388-397. doi:10.1001/archderm.1931.03880200178018

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Acanthosis Nigricans, Juvenile Type. Presented by Dr. H. E. Michelson.  A girl, aged 17, presented a verrucous eruption in both axillae, about the umbilicus and at the sides of the neck. There were no subjective symptoms and no signs of inflammation. The patient was a distinct "endocrine" type; she weighed 225 pounds (102 Kg.) and was 5 feet, 6 inches (167.6 cm.) in height. The basal metabolism was plus 10. Roentgenograms of the skull showed no abnormalities of the sella, and there was no history of ovarian dysfunction. A biopsy showed a papilliform arrangement of the epidermis with an increase of pigment in the basal layer. The cells in the cutis showed pigment. There were no signs of inflammation. (A biopsy specimen was shown).

DISCUSSION  Dr. Paul O'Leary, Rochester: The presumptive diagnosis of acanthosis nigricans seems justified at this time, but a subsequent observation will be necessary to determine whether

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