The condition known in America as keratolysis exfoliativa was named by Wende1 in 1919, who described it as characterized by more or less symmetrical, circumscribed patches of superficial exfoliation encountered most frequently on the palms, less often on the soles and occasionally on the dorsal surfaces of the hands and feet and on the arms and legs. Caryon,2 unknown to Wende, had previously written of a similar disease under a different title, and Lane3 concluded that the two diseases were identical. More recently, several observers in Europe, notably Seemann and Rajka4 and Alexander,5 studied the disease. Bruhns and Alexander,6 in Jadassohn's "Handbuch," gave an excellent detailed description of it under the title "dysidrosis lamellosa sicca."
The disease is common and is seen in varying degrees of severity. It begins with white macules, varying in size from that of a pinhead to that of a
MacKEE GM, LEWIS GM. KERATOLYSIS EXFOLIATIVA AND THE MOSAIC FUNGUS. Arch Derm Syphilol. 1931;23(3):445–471. doi:10.1001/archderm.1931.03880210038004
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