In the field of immunology many formerly purely theoretical points of view have recently found experimental confirmation or rebuttal. Most of the experiments of the last few years have tended to confirm the theory that a great many of the various types of hypersensitiveness are due to the presence of cell-fixed antibodies. Without going into the detail of this consideration, it might be said that it offers an explanation for many of the otherwise inexplicable immunologic phenomena which are encountered in human pathology, including the pathologic reactions of the skin. It explains the hypersensitive reaction of certain tissues, and of those tissues only, in spite of the existence of generalized contact with the exciting substance. Of the many possible examples we need cite only the following: Pollen enters the respiratory tract of the patients, A and B. Both are hypersensitive to the pollen in question, and the pollen comes in
SULZBERGER MB, WISE F. THE CONTACT OR PATCH TEST IN DERMATOLOGY: ITS USES, ADVANTAGES AND LIMITATIONS. Arch Derm Syphilol. 1931;23(3):519–531. doi:10.1001/archderm.1931.03880210112009
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