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May 1931


Author Affiliations

Clinical Assistant in Dermatology, Louisville City Hospital LOUISVILLE, KY.

From the Vanderbilt Clinic and the Department of Dermatology, Columbia University, New York.

Arch Derm Syphilol. 1931;23(5):874-883. doi:10.1001/archderm.1931.03880230050006

Following Schamberg's introduction of gold sodium thiosulphate in the treatment for lupus erythematosus, several reports appeared on the use of this and similar compounds. For three years these drugs have been widely employed, and it now seems that an attempt to appraise their value in the light of a longer experience would be worth while.

The use of gold compounds in the treatment of patients with lupus erythematosus dates from 1913, when Reute1 first reported the use of gold potassium cyanide in a case lupus erythematosus. From that time until almost ten years later, little was written on this type of therapy, although in 1917 Adolf Feldt2 had prepared a new gold compound, 4-amino-2-aurothiophenol carbonic acid, and had been using it with considerable success in the treatment for various types of systemic tuberculosis.

In 1921, Kohrs3 reported a case of lupus erythematosus with cure by this drug,

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