The therapy described in this paper was suggested by a series of experiments carried out in studying the results of treatment with vaccine in animals made hypersensitive to streptococci in an attempt to find a basis for vaccine therapy in acute rheumatic fever.
These animals were made hypersensitive (allergic) by subcutaneous injection into one area of agar at 45 C. heavily seeded with streptococci. This method of producing and maintaining an allergic state had been demonstrated by Swift.1 In from twelve to eighteen days after the initial sensitizing dose, the animals were given subcutaneous injections by the method previously used in producing experimental rheumatoid subcutaneous nodules.2 Into ten places on the right side of the back of each animal was injected subcutaneously 11/100 of a standard amount of streptococci and into ten places on the left side,1/1,000 of the amount. In a former series of experiments with increasing
CLAWSON BJ, ALLEN PK. INTRAVENOUS VACCINE THERAPY IN STAPHYLOCOCCIC INFECTIONS. Arch Derm Syphilol. 1931;23(5):894–900. doi:10.1001/archderm.1931.03880230070008
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