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June 1931


Author Affiliations


From the University of Pennsylvania Graduate School of Medicine and the clinic of Dr. J. Frank Schamberg.

Arch Derm Syphilol. 1931;23(6):1064-1068. doi:10.1001/archderm.1931.03880240045005

A survey of the literature of the past ten years would make it appear that the quantitative changes in blood sugar in various pathologic conditions had been thoroughly studied. In more recent years, the dermatoses have been included among these pathologic states. However, the objects of the present study were: (1) to try to throw additional light on the pathogenesis of acne vulgaris by means of tests of tolerance for dextrose; (2) to determine whether or not a concealed intolerance might not explain why pustulation is so common in this disease.

Simple acne vulgaris is undoubtedly closely related to the activity of the endocrine glands, as evidenced by the facts that it develops at or shortly after puberty; that it disappears when these disturbances of puberty have apparently become harmonized or balanced, and that in females it has a tendency to become more marked at menstrual periods.

Although glycogenolytic activities

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