The last decade has witnessed a period of great activity in the development of serologic procedures for the detection and control of syphilis. The literature on this subject is too voluminous to warrant a complete résumé. In general, excellent agreement of methods is recorded with regard to the diagnosis1 of syphilis, and some investigators have reported that the majority of discordant results in serologic tests occur in latent cases and in old cases in which treatment has been given.2 From the points of view of both diagnosis and control of treatment, these methods include the complement-fixation procedures of Kolmer and the New York State Department of Health and the precipitation or flocculation tests of Hinton, Kahn, Kline, Meinicke (Meinicke-Klärungsreaktion), Müller (Müller-Ballungsreaktion), Sachs-Georgi and Vernes. None of these investigators employed all of the aforementioned methods; in fact, usually only three or four methods were included in a study.
KURTZ MB, ZENTMIRE Z. SEROLOGIC TESTS FOR SYPHILIS, WITH SPECIAL REFERENCE TO TREATMENT: A COMPARATIVE STUDY. Arch Derm Syphilol. 1931;24(1):104–107. doi:10.1001/archderm.1931.01450010109009
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