During the last few years there has been a great advance in the treatment for lupus erythematosus with various gold compounds. Much has been written concerning the toxicity of these preparations, all of which have been administered by the intravenous method. Many cases have been encountered in which more than 100 intravenous injections have failed to produce cure, and others in which a few carefully given doses were followed by more or less serious reactions, exfoliating dermatitis and, in a number of instances, death. To avoid these complications, experimentation was begun to determine a method of giving this valuable group of compounds which would be equally or more efficient than the intravenous route, but which would not be as hazardous. Furthermore, it seemed to us that if the beneficial results of gold compounds in lupus erythematosus depended on their reaching the diseased areas, injection directly into the lesion
MONASH S, TRAUB EF. MODIFICATION OF THERAPY WITH GOLD COMPOUNDS IN LUPUS ERYTHEMATOSUS: PRELIMINARY COMMUNICATION. Arch Derm Syphilol. 1931;24(1):110–111. doi:https://doi.org/10.1001/archderm.1931.01450010115011
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