That artificial heat possesses curative activity in syphilis in rabbits has been shown by the investigations of Schamberg and Rule.1 Hot baths, for eleven consecutive days, under certain conditions, with an average rise in temperature of about 4 F., usually protected the animals from syphilis after intratesticular inoculation with virulent Spirochaeta pallida; hot baths were subsequently found to reduce the strength of the Kolmer-Wassermann reaction in human beings,2 with a regression of secondary and tertiary lesions.
Since the advent of malarial therapy in the treatment for syphilis, other agents have been tried for the production of fever, among which may be mentioned sodium nucleinate, tuberculin, typhoid vaccine and Coley's fluid, the literature having been briefly summarized by Kemp and Stokes,3 who also reported on the extensive use of typhoid-para-typhoid vaccine by intravenous injection in the treatment for acute and chronic syphilis in human beings. Their average
KOLMER JA. BACTERIAL PROTEIN FEVER IN THE TREATMENT OF SYPHILIS IN THE RABBIT. Arch Derm Syphilol. 1931;24(4):546–553. doi:https://doi.org/10.1001/archderm.1931.01450010556003
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