The relative ineffectiveness of most remedies for diseases of the central nervous system is a subject of much interest and importance. That a great number of chemical and biologic substances do not penetrate into nerve tissue and the spinal fluid in appreciable concentration is a well known fact. Under normal conditions there is a competent barrier between the nervous system and many of the ingredients of the blood within the cranial and the spinal vessels. This has been called the hemato-encephalic barrier. It is illustrated by the absence of staining of nerve tissue and spinal fluid in cases of jaundice. The numerous recommendations, both as to remedy and as to method, concerning the treatment for neurosyphilis confirm these statements.
Some of the suggested explanations of this barrier are: (1) the atypical vascular distribution and the absence of lymphatics, (2) the inelasticity of the covering of the brain and the
SMITH DC, WADDELL JA. JUGULAR COMPRESSION: AN ADJUNCT IN THE TREATMENT OF SYPHILIS OF THE CENTRAL NERVOUS SYSTEM. Arch Derm Syphilol. 1931;24(5):727–732. doi:10.1001/archderm.1931.01450010739002
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