Several years ago Folin, Trimble and Newman1 injected dextrose intravenously into animals and observed that shortly thereafter the quantity of reducing substances found in the skin was considerably increased. They took a series of specimens of this tissue from the same anesthetized animal previous to, and at regular intervals after, an injection of sugar, and noted that the content of reducing substances in the skin quickly rose to a level slightly less than that in the blood. It then declined in a manner such that it remained beneath, but more or less paralleled, that in the circulating fluid. At the time that investigation was made, the analytic methods available were sufficient to measure merely the total amount of reducing substances contained in the tissue examined, and it was not possible then to state with certainty just how much of this represented actual sugar. Recent improvements in
TRIMBLE HC, CAREY BW. THE TRUE SUGAR CONTENT OF THE SKIN IN DIABETES. Arch Derm Syphilol. 1932;25(1):6–10. doi:10.1001/archderm.1932.01450020014002
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