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Article
March 1932

LX.—THE EFFECT OF THALLIUM ACETATE ON THYROIDECTOMIZED ALBINO RATS

Arch Derm Syphilol. 1932;25(3):522-527. doi:10.1001/archderm.1932.01450020538010
Abstract

In recent years the use of thallium acetate as a depilatory in cases of ringworm of the scalp has focused considerable attention on this drug. Clinically, a single dose of 0.008 Gm. of thallium acetate per kilogram of body weight given by mouth is sufficient to cause the hair of the scalp to fall. The drug can be used with safety only in children who have not yet reached the age of puberty. The question of how the drug acts within the body in order to produce its characteristic effect on the hair is still unsettled. Four theories have been proposed to explain its action: (1) that thallium acts directly on the hair follicle; (2) that the drug affects primarily the central nervous system, and that the effects on the hair are secondary; (3) that thallium affects the sympathetic nervous system and through it the hair ; (4) that thallium directly

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