Wright1 was probably the first to use calcium therapy in dermatology thirty-five years ago in the treatment for urticaria. Since then calcium therapy has been widely used in the treatment for urticaria, eczema and dermatitis. There seems to be fairly general agreement that calcium therapy is of distinct value in the treatment for certain dermatoses. Nearly all of the favorable results reported are based on clinical evidence. Attempts to demonstrate the mode of action of calcium in animals, as well as attempts to show calcium deficiencies in patients with urticaria and dermatitis, have, for the most part, been unsuccessful. The futility of seeking a relation between minor fluctuations of serum calcium values and inflammations of the skin in patients has been demonstrated by Klauder and Brown,2 Schamberg and Brown,3 Brown and Greenbaum,4 Nathan and Stern5 and others.
In the studies of Luithlen,6
SCHOCH AG. INFLUENCE OF VIOSTEROL HYPERCALCEMIA ON SKIN IRRITABILITY OF DOGS. Arch Derm Syphilol. 1932;25(5):835–839. doi:10.1001/archderm.1932.01450020861007
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