[Skip to Navigation]
Article
July 1932

CHOLESTEROL METABOLISM IN CERTAIN DERMATOSES: WITH SPECIAL REFERENCE TO ACNE VULGARIS

Author Affiliations

PHILADELPHIA

Arch Derm Syphilol. 1932;26(1):11-20. doi:10.1001/archderm.1932.01450030014002
Abstract

Numerous studies in recent years have attempted to relate various skin diseases to changes in the composition of the blood. The results of such studies have been largely disappointing, showing either the constituents determined to be normal or the variations so irregular as to make deductions therefrom impossible.

The high content of cholesterol and its esters as well as of other sterols in the normal skin secretion makes its variations an interesting subject as a possible predisposing factor in certain dermatoses. The fact that cholesterol plays a prominent part in lymphoid defense, its ability to protect blood cells from hemolysis and the universal presence of cholesterol or related sterols in plant and animal cells might lead one to suspect cholesterol of a prominent part in the etiology or course of such inflammatory diseases as acne and psoriasis, or the seborrheic dermatoses in which the skin may secrete either excessive or

Add or change institution
×