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Article
February 1933

SENSITIZATION AND DESENSITIZATION IN MAN WITH SNAKE VENOM (ANCISTRODON PISCIVORUS)

Arch Derm Syphilol. 1933;27(2):312-315. doi:10.1001/archderm.1933.01450040317013
Abstract

Experimentation on rabbits has shown that a small amount of moccasin venom given intradermally produces, after an incubation period, a refractory state to the experimental purpura, known as the Shwartzman phenomenon.1 In an effort to discover whether snake venom could serve as a nonspecific method for raising the resistance of vessels to hemorrhage, an attempt was made to treat diseases such as thrombocytopenic purpura, hemophilia, familial hemorrhagic tendencies and functional uterine bleeding with this substance. In addition, various allergic diseases, such as hay fever and urticaria, were also treated. A preliminary report on the clinical results obtained has been published.2 This report deals with the development of cutaneous sensitivity following repeated injections of the venom in a group of allergic patients and in a group treated for hemorrhagic tendencies.

METHOD OF ADMINISTRATION

The venom used was that of the moccasin snake (Ancistrodon piscivorus). It

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