In recent communications Barber and Oriel1 have described a complex proteose substance in the urine. This proteose is obtained from normal urine in small amounts, but is markedly increased in the asthma-eczema-hay fever complex and in cases of urticaria, simple prurigo and dermatitis herpetiformis. Furthermore, these authors have claimed that in active allergic dermatoses the patient's proteose, when injected intradermally into his skin, gives rise to a specific, inflammatory cutaneous reaction. When injected intradermally into other patients with allergic or nonallergic dermatoses, the reactions are consistently negative. Lastly, they have contended that increasing amounts of proteose injected intradermally, and perhaps later subcutaneously (as in vaccine therapy), in the aforementioned type of cases, bring about a desensitization of the allergic body cells and effect prolonged and sometimes permanent remissions. They do not claim to know the exact nature of this proteose. They describe a complex protein
CORMIA FE. URINARY PROTEOSE: ALLERGIC DERMATOSES AND THE ECZEMA-ASTHMA-HAY FEVER COMPLEX. Arch Derm Syphilol. 1933;27(5):745–750. doi:10.1001/archderm.1933.01450040754003
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