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Arsenic-Resistant Syphilis. Presented by Dr. C. D. Freeman, St. Paul.
H. S., a white man, aged 38, first saw the presenter in January, 1932, because of crusted lesions on the arms and thighs about 2 to 5 cm. in diameter. Following intravenous and intramuscular therapy, the lesions involuted, leaving pigmentation. About April 5, moist lesions began to develop, extending from the angle of the mouth. On admission of the patient to the University Hospital, in April, there were crusted lesions on the trunk and extremities. A course of malaria therapy was given. Tests of the spinal fluid gave negative results, but Wassermann tests of the blood have been persistently positive. The lesions involuted partially, and the patient continued therapy with mercury and silver arsphenamine. In August he was again referred to the University Hospital for a course of arsphenamine therapy. Seven injections were given, and also seven injections of neoarsphenamine.
Shapiro EZ. MINNESOTA DERMATOLOGICAL SOCIETY. Arch Derm Syphilol. 1933;27(6):1015–1019. doi:10.1001/archderm.1933.01450041025020
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