The greater frequency of nonsyphilitic ulcerations on the left leg has been pointed out by Goodman1 as of importance for the differential diagnosis. In a series of 64 cases of ulcer of the lower part of the leg he obtained negative Wassermann reactions in 73 per cent of 26 patients with ulcers limited to the left leg, as compared with negative reactions in only 40 per cent of 25 patients with ulcers of the right leg. Of 13 patients with ulcers on the lower part of both legs 85 per cent had a negative Wassermann reaction. Goodman concluded that in his series this predominance of nonsyphilitic ulcers on the left side was due to anatomic peculiarities of the larger, higher veins, resulting in retarded venous circulation more often in the left than in the right leg.
The present analysis comprises 175 cases of ulcus cruris chosen without selection. A
HASSELMANN CM. ULCER OF THE LEG: ITS LOCALIZATION AS A POINT OF DIFFERENTIAL DIAGNOSIS IN SYPHILIS AND YAWS ENDEMIC COUNTRIES. Arch Derm Syphilol. 1933;28(1):44–52. doi:10.1001/archderm.1933.01460010047010
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.