Knowledge of the chemical reaction that occurs in topical preparations employed for cutaneous diseases is notably deficient. In general, the effect of external treatment depends mainly on the physical properties of the pharmaceutical products.
In a paper published recently,1 a report was made of the results obtained by determining the hydrogen ion concentration of the skin in cases of eczema. Itwas found that in these cases, and especially in the acute ones, the pH was increased—that is, there was a more marked alkaline reaction. We therefore believed that in a rational treatment of the dermatoses it would be valuable to know the reaction of the topical preparations that are used most frequently.
A survey revealed that there was a distinct paucity in literature regarding the chemical reactions of cutaneous topical preparations. Previous investigators had determined only the reaction of the watery applications. No attempts had been made to
LEVIN OL, SILVERS SH. THE HYDROGEN ION CONCENTRATION OF THE TOPICAL PREPARATIONS COMMONLY EMPLOYED IN DERMATOLOGY. Arch Derm Syphilol. 1933;28(2):149–152. doi:10.1001/archderm.1933.01460020003001
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