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Article
August 1933

THE HYDROGEN ION CONCENTRATION OF THE TOPICAL PREPARATIONS COMMONLY EMPLOYED IN DERMATOLOGY

Author Affiliations

Attending Dermatologist, Beth Israel, Sea View and Queens General Hospitals; Associate Dermatologist, Mount Sinai and Montefiore Hospitals; Consulting Dermatologist, Rockaway Beach and St. Joseph's Hospitals; Adjunct Dermatologist, Beth Israel Hospital; Assistant Attending Dermatologist and Syphilologist, Bellevue and New York University Medical Clinic NEW YORK

Arch Derm Syphilol. 1933;28(2):149-152. doi:10.1001/archderm.1933.01460020003001
Abstract

Knowledge of the chemical reaction that occurs in topical preparations employed for cutaneous diseases is notably deficient. In general, the effect of external treatment depends mainly on the physical properties of the pharmaceutical products.

In a paper published recently,1 a report was made of the results obtained by determining the hydrogen ion concentration of the skin in cases of eczema. Itwas found that in these cases, and especially in the acute ones, the pH was increased—that is, there was a more marked alkaline reaction. We therefore believed that in a rational treatment of the dermatoses it would be valuable to know the reaction of the topical preparations that are used most frequently.

A survey revealed that there was a distinct paucity in literature regarding the chemical reactions of cutaneous topical preparations. Previous investigators had determined only the reaction of the watery applications. No attempts had been made to

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