Since 1918, when Wagner-Jauregg,1 in Vienna, and Mühlens and his associates,2 in Hamburg, began the malaria treatment of neurosyphilis on a large scale, this original form of fever therapy has been used extensively throughout the world. I shall attempt to summarize its present status before discussing the newer methods.
Method of Inoculation.—
From 2 to 10 cc. of whole blood taken from a person suffering with tertian malaria is inoculated into a neurosyphilitic patient. Of course, the original inoculation must be made from a person who has acquired malaria naturally, but, as such material is rare in many parts of the world, most inoculations are made from donors who have acquired the disease artificially; these inoculations seem to be just as successful whether the blood is taken at the time of a paroxysm or during the interval between chills; nor does there seem to be any necessity
BECKMAN H. A BRIEF REVIEW OF FEVER THERAPY IN NEUROSYPHILIS. Arch Derm Syphilol. 1933;28(3):309–319. doi:10.1001/archderm.1933.01460030003001
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.