Within the past few years a number of bismuth preparations have been placed at our disposal. The ever increasing number and variety of compounds have confused the physician to such an extent that he is unable properly to appraise their value and to choose correctly the one that is best adapted to his particular case. Shall he use a soluble compound, an insoluble one or one containing both a soluble and an insoluble salt? Is the intramuscular route preferable to all others? How do these various compounds affect the human organism? It was with these problems in view that we undertook this investigation in an effort to clarify the situation.
We have attempted to study the effect of bismuth preparations on the (1) resolution of cutaneous lesions, (2) hepatic and renal functions, (3) blood pressure, (4) hemoglobin and red blood cells, (5) Wassermann reaction of the blood, (6) disappearance of
IRGANG S, ALEXANDER ER, SALA AM. BISMUTH COMPOUNDS IN THE TREATMENT OF ACTIVE SYPHILIS: A CLINICAL AND LABORATORY STUDY OF TWO HUNDRED AND EIGHTY-SIX CASES OF CUTANEOUS SYPHILIS. Arch Derm Syphilol. 1933;28(3):320–352. doi:10.1001/archderm.1933.01460030014002
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