The fourth venereal disease, lymphogranuloma inguinale (synonyms —climatic bubo, strumous bubo and lymphopathia venerea), has recently attracted much attention in this country, as is shown by the increasing number of publications and demonstrations on this subject.
The transitory nonsyphilitic primary lesion on the penis with the subacute inflammation of the inguinal lymph nodes, followed, if untreated, by suppuration and by formation of sinuses of many months' duration, has been observed in various parts of the United States.
The fact that Wolf and Van Cleve observed fifty-eight cases in Cleveland in less than two years indicates that the disease is prevalent, and suggests that the apparent rarity of cases in other communities may be due to incorrect diagnosis. For instance, as late as 1927, there appeared a description by Barber and Coogle1 of five cases in Mississippi under the name of "non-tuberculous granulomatous lymphadenitis." The authors apparently were unaware that
CURTH W. EXTRAGENITAL INFECTION WITH THE VIRUS OF LYMPHOGRANULOMA INGUINALE. Arch Derm Syphilol. 1933;28(3):376–380. doi:10.1001/archderm.1933.01460030070006
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