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Article
October 1933

VITILIGO: A CLINICAL AND HISTOLOGIC STUDY, WITH A CONSIDERATION OF PINTA

Author Affiliations

From the Section of Dermatology of the Department of Medicine, the University of Chicago. Read in part at the Scientific Session of the Section of Dermatology, Nov. 6, 1931.

Arch Derm Syphilol. 1933;28(4):497-507. doi:10.1001/archderm.1933.01460040040004
Abstract

Since the advent of modern study of pigment, little has been done toward the solution of the problem of vitiligo. Bloch1 noted absence of the dioxyphenylalanine reaction in the depigmented region. Miescher2 utilized a patch of vitiligo in some of his studies of chromatophores and found that chromatophores in the depigmented areas take up melanin injected intradermally. McCarthy3 stated that the histologic change consists of disappearance of the chromatophores (melanoblasts [S.W.B.]) from the cells of the lower portion of the epithelium. Gans4 noted partial or complete depigmentation of the patches of vitiligo with hyperpigmentation of the border. He stated that inflammatory and atrophic changes have been observed, along with nerve changes of the atrophic type. He appropriately called attention to the difficulty in interpretation of cutaneous nerve sections. Nadel5 studied the pigment which had appeared in treated vitiliginous patches and determined it to be melanin.

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