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The conventional method of applying the patch test, in an effort to determine the causative eczematogenous substance in contact eczema, consists in placing the substance to be tested on the skin of the forearm, back or thigh of the subject, covering it with an impermeable material such as cellophane or waxed paper and anchoring the latter to the skin by means of adhesive tape. The adhesive plaster acts as a dermal irritant in a large proportion of the cases. The resulting dermatitis not only interferes with the proper subsequent readings of the tests but frequently causes an annoying transient dermatitis, especially when a large number of patches are applied. To obviate the objectionable feature of this method, a substitute for the adhesive material was sought.
Various types of glue and liquid cement were employed for anchoring the covering material to the skin. The glues and several brands of cement were
SHELMIRE B. CONTACT ECZEMA: RUBBER CEMENTS AS ADHESIVE IN PATCH TESTING. Arch Derm Syphilol. 1933;28(6):795–797. doi:10.1001/archderm.1933.01460060032005
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