In his excellent monograph on immunity in syphilis, Chesney1 cited the more important attempts made prior to 1927 to produce an artificial active immunity against experimental syphilis in rabbits. In general, the procedures employed proved to be unsuccessful in creating even a partial immunity to subsequent inoculation with virulent Spirochaetae pallidae. Since 1927 further efforts to immunize rabbits against experimental syphilis have been reported. Thus Honda2 obtained no evidence of immunity in rabbits as the result of repeated injections of a phenolized virus emulsion prepared from syphilitic testes. Pearce3 found that experimental syphilis was less severe in rabbits rendered immune to the virus of vaccinia. Kolmer4 obtained entirely negative results with phenolized and formaldehydized vaccines prepared from the syphilitic testes of rabbits. Schöbl, Tanabe and Miyao5 reported that in rabbits treated with yaws vaccine local lesions failed to develop at the site of subsequent inoculation
WAKERLIN GE. ATTEMPTED IMMUNIZATION OF RABBITS AGAINST EXPERIMENTAL SYPHILIS. Arch Derm Syphilol. 1933;28(6):843–846. doi:10.1001/archderm.1933.01460060080014
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