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Article
January 1934

MULTIPLE GANGLIONEUROMAS OF THE SKIN: REPORT OF A CASE WITH DIFFERENTIAL DIAGNOSIS FROM RETICULOHISTIOCYTIC GRANULOMA, NEUROMA, XANTHOMA AND RECKLINGHAUSEN'S DISEASE OF THE SKIN

Author Affiliations

ROCHESTER, MINN.

From the Section on Dermatology and Syphilology, the Mayo Clinic.

Arch Derm Syphilol. 1934;29(1):26-52. doi:10.1001/archderm.1934.01460070029004
Abstract

We shall report a case in which there were multiple nodules of the skin. The case, clinically, suggested the diagnosis of multiple xanthoma, but we feel that it was one of multiple ganglioneuromas of the skin in which the nodules had their origin in the tissue of the peripheral sympathetic nervous system and probably are best explained as malformation (Missbildung). The diagnosis at which we finally arrived was first suggested by Dr. James W. Kernohan, of the Mayo Clinic, who gave us assistance regarding the pathologic problems that were encountered. Because most of the dermatologists who saw the patient felt that the clinical diagnosis of multiple xanthoma was warranted (at one time the yellowish hue was less apparent and suggested the diagnosis of sarcoid), and because the histopathologic findings were inconsistent with the diagnosis of xanthoma, we submitted sections for study to various pathologists, neuropathologists and dermatopathologists. Their replies indicated

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