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February 1934


Author Affiliations


From the Department of Pharmacology and the Neuropsychiatric Division of the Department of Medicine, Stanford University School of Medicine.

Arch Derm Syphilol. 1934;29(2):298-306. doi:10.1001/archderm.1934.01460080128012

This paper presents the final results on the urinary and fecal excretion of bismuth after the administration of iodobismitol in man and in animals. Since the publication of a preliminary report,1 the number of subjects for this study has been increased, the total number of human beings being twenty-two, and the number of rabbits, thirteen. For one reason or another, not all human beings and animals permitted the study of complete excretion. Satisfactorily completed excretions were obtained with ten persons and seven rabbits.

METHODS  The iodobismitol was injected intramuscularly in both patients and rabbits. The iodobismitol contained 6 per cent sodium iodobismuthite (containing 21.5 per cent bismuth) and 12 per cent sodium iodide in ethylene glycol (description in "New and Nonofficial Remedies"). The doses used were of therapeutic order, ranging from a single dose of 0.033 cc. per kilogram (2 cc. for an adult weighing 60 Kg.) to multiple

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