Reported studies of the penetration of bismuth into the nervous system have been conflicting. The results of studies of the penetrability of nerve tissue for bismuth by a number of investigators have been reviewed in recent reports by Hanzlik and his collaborators1 and need not therefore be detailed. Bismuth has rarely been found in the spinal fluid of patients into whom a bismuth compound has been injected, and only occasional traces have been found in the brains of laboratory animals into which massive doses of bismuth compounds have been injected. Hanzlik and his collaborators,2 however, employing a new bismuth compound, sodium iodobismuthite (iodobismitol), which is later discussed, have reported a high degree of penetrability of the nervous system for this compound. On the other hand, Levaditi, Vaisman, Manin and Schoen3 were unable to find bismuth in the spinal fluid of patients into whom sodium iodobismuthite was injected.
KLAUDER JV, BROWN H. THE QUESTION OF BISMUTH PENETRATION OF THE NERVOUS SYSTEM: REPORT OF CLINICAL AND LABORATORY STUDY. Arch Derm Syphilol. 1934;29(3):351–355. doi:10.1001/archderm.1934.01460090020003
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