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Article
April 1934

INTRADERMAL TESTS IN RELATION TO ARSPHENAMINE DERMATITIS: A STUDY BASED ON TWO HUNDRED AND FIFTY-SIX CLINICAL CASES

Author Affiliations

NEW YORK

From the Vanderbilt Clinic, Columbia University College of Physicians and Surgeons.

Arch Derm Syphilol. 1934;29(4):485-520. doi:10.1001/archderm.1934.01460100003001
Abstract

Introduction

Method and Technic

Time and Number of Tests

Observation after Tests

Types of Reactions

Immediate, Early and Delayed Reactions

"Positive" Reactions

Reactions to First and Later Tests Compared

Tests in Patients With and Without Arsphenamine Therapy

Intradermal Tests in Tolerant as Compared with Intolerant Patients

Tests in Patients without Arsphenamine Therapy

Intradermal Test as an Aid in Diagnosis and Prognosis of Complications from Arsphenamine Therapy

The Test in Diagnosis: Specificity

Reactions to Different Arsphenamines

Differences in Reaction to Arsphenamines and to Other Arsenical Preparations

Epidermal Reactions as Compared with Other Types

The Test in Prognosis

Syphilitic Patients not yet Treated with the Arsphenamines

Syphilitic Patients Previously Tolerant of the Arsphenamines

Sensitization and Desensitization

The Test as a Sensitizer

Reaction of Patients to Subsequent Intravenous Injections

Reaction of Patients to Repeated Intradermal Tests

Arsphenamine Dermatitis as a Phenomenon of Sensitization

Dermatitis after Few Injections and Small Doses

Polyvalent Sensitization

Rôle

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