The contribution of Williams1 in suggesting the probable allergic nature of erythematosquamous and vesicular lesions of the hands or "phytids" in association with fungus infections of the feet has opened up entirely new methods of approach to many hitherto obscure and intractable eruptions. Based on the original observations of Jadassohn2 and Bloch,3 who described secondary allergic reactions to deep fungus infections, Williams' conception of a similar process in the superficial fungus infections has received ample confirmation by Wise, Sulzberger, Peck, W. Jadassohn and others.4
These secondary phytids have been likened to tuberculids that result from some primary focus of infection. Recent trends of opinion regard these lesions as manifestations of an allergic or hypersensitive state of the tissues. Since fungi are usually easily demonstrated in the original areas of infection, which most commonly occur on the feet, and are usually absent in the secondary lesions, which
AYRES S, ANDERSON NP. INHIBITION OF FUNGI IN CULTURES BY BLOOD SERUM FROM PATIENTS WITH "PHYTID" ERUPTIONS. Arch Derm Syphilol. 1934;29(4):537–547. doi:10.1001/archderm.1934.01460100055005
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