Systematized amyloidosis is the name which Lubarsch proposed for a form of amyloidosis which was atypical for generalized amyloidosis, but which involved far too much tissue to be classed as a localized form. The cases of systematized amyloidosis observed by Lubarsch1 had certain features in common, thus establishing a fairly well defined syndrome; but specific cutaneous manifestations were not constant, although they were present in a high percentage of the patients observed.
Generalized amyloidosis, as originally described, consisted of changes in the large abdominal viscera accompanying such diseases as syphilis, tuberculosis, blastomas and some chronic suppurations. These diseases apparently have the faculty of altering protein metabolism in such a way as to produce amyloid.
Atypical deposits of amyloid were soon recognized, and Ziegler2 called attention to the most common form when, in 1875, he demonstrated amyloid deposits strictly limited to the tongue and larynx. Such isolated involvement has
MICHELSON HE, LYNCH FW. SYSTEMATIZED AMYLOIDOSIS OF THE SKIN AND MUSCLES. Arch Derm Syphilol. 1934;29(6):805–820. doi:https://doi.org/10.1001/archderm.1934.01460120002001
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