During the past ten years, precipitation tests for syphilis have been rapidly assuming a place of increasing importance in serodiagnosis. During this same period, the complement-fixation tests have also been undergoing modification and standardization. In clinical work the questions arise as to which tests to use and as to the relative reliance which may be placed on them. From the practical standpoint, any test must be judged by the following criteria: (1) sensitivity and specificity, (2) ease in reading results, (3) simplicity of performance (including the use of apparatus and biologic materials), (4) rapidity of performance and (5) the purpose for which the test is to be used. Obviously, a test which meets these requirements, is sufficiently sensitive and is easily performed will best meet the demands of the clinician. The amount of serum required for the test is sometimes also important, as in the case of infants.
RITCHIE EB, HERRICK R, van de ERVE JM. PRACTICAL CLINICAL AND LABORATORY ASPECTS OF PRECIPITATION TESTS FOR SYPHILIS. Arch Derm Syphilol. 1934;29(6):835–844. doi:10.1001/archderm.1934.01460120032003
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