In our study of the complex of rosacea we1 were impressed with the variety of factors (especially nervous, gastro-intestinal and seborrheic) which were involved in the individual patient, and we concluded that the rational treatment of rosacea must concern itself chiefly with the constitutional indications. This concept is not new, as the studies of Ryle and Barber,2 Lortat-Jacob and Legrain,3 Brown,4 Rulison,5 Eastwood6 and Hachenburg7 have stressed seriatim an increasing appreciation of the variety of factors involved, especially the gastro-intestinal factors. Sellei8 summarized this view of the situation by stating, "Rosacea exists as a result of internal causes.... One should never be satisfied with the external treatment alone, but should also take into account the internal treatment of the etiological factors." In contrast, the results of Ayres and Anderson9 are startling. These authors stated that it is not "necessary to search
BEERMAN H, STOKES JH. ROSACEA COMPLEX AND DEMODEX FOLLICULORUM. Arch Derm Syphilol. 1934;29(6):874–884. doi:10.1001/archderm.1934.01460120071006
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