As there appears to be evidence of the presence of a toxic substance in the blood serum in pemphigus,1 it is reasonable to assume that this substance is present in relatively large quantities in the blood stream in the last few hours preceding death due to this disease.
In this paper an attempt has been made to demonstrate the presence of this toxic substance by determining the effect of intravenous injection of pemphigus serum on the white cell count of rabbits.
The material used for the study was blood serum taken from two fatal cases of pemphigus within twenty hours preceding death. The histories of the cases, together with certain studies of the blood and bacteriology made thereon, have already been reported.
In the carrying out of this work it was necessary to establish a normal base line for the rabbits' differential white cell count before the injection of
GRACE AW, Ross E. PEMPHIGUS: EFFECT OF PEMPHIGUS SERUM ON THE LEUKOCYTIC PICTURE OF RABBITS. Arch Derm Syphilol. 1934;29(6):885–886. doi:10.1001/archderm.1934.01460120082007
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: