Recently a quantitative study was made of the hydrogen sulphide content of some of the lotions used in the topical treatment of acne. This research gave reason to believe that the old lotio sulphurata held fewer sulphide ions than the new. In other words, the effectiveness of lotio sulphurata depends on the presence of sulphide ions, which in theory was conceded to depend on the hydrogen ion concentration of the solution. From these experiments, it was thought that a knowledge of the hydrogen ion concentration would be of considerable aid in the preparation and storage of lotions employed in the topical treatment of acne.
Prof. Abraham Taub of the College of Pharmacy of Columbia University did these determinations. He used the quinhydrone electrode potentiometer. The possibility of error with this type of electrode is conceded, but such error is held to be constant for the tests reported in this article.
GOODMAN H, Taub A. HYDROGEN ION CONCENTRATION OF LOTIONS USED IN TREATMENT OF ACNE. Arch Derm Syphilol. 1934;30(1):6–8. doi:10.1001/archderm.1934.01460130014002
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