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July 1934


Arch Derm Syphilol. 1934;30(1):33-43. doi:10.1001/archderm.1934.01460130041008

MANIFESTATIONS OF ARSENIC POISONING  This paper is concerned primarily with the cutaneous manifestations of arsenic poisoning. As is well known, arsenic may damage practically any organ or tissue in the body and may therefore indirectly account for many unusual clinical manifestations. Arsenical damage to nerve, neurocirculatory or endocrine tissue, for instance, may produce cutaneous symptoms not regarded as typical of arsenic poisoning.

Allergic Reactions: Erythematous and Exfoliative Eruptions.—  The fact that after recovery a severe relapse may be induced by even minute quantities of arsenic speaks for the allergic nature of this symptom complex. In addition to the aforementioned lesions, the eruption may be urticarial, scarlatiniform, morbilliform, pityriasiform and lichenoid, of the planus or the spinulous type. Occasionally the eruption takes the form of a fixed erythema resembling an eruption due to phenolphthalein, flaring up after each exposure to arsenic, subsiding and again flaring up in the same location, usually