2 The literature reveals a wide disparity of opinion in regard to the etiology and methods of treatment of verrucae. Many authors consider the cause to be unknown; some believe that warts are caused by fungi or yeasts. Chavarria1 isolated a mycotic organism. Bonjour advanced a psychovasomotor theory of etiology and stated the belief that a psychically induced local vasomotor congestion will often cause the lesions to disappear. However, it has been conclusively demonstrated that by far the greatest proportion of verrucae are caused by a filtrable virus, the nature of the further pathogenicity of which is unknown.
As early as 1895 Jadassohn3 suggested that the infectious nature of verrucae was not due to bacteria. In 1907, Ciuffo4 stated the belief that a virus was the causal agent, and he succeeded in producing a verrucous lesion with autolysate material which had been passed through a Berkefeld filter.
FRANK E. CORMIA. AUTOLYSATE THERAPY FOR VERRUCA VULGARIS. Arch Derm Syphilol. 1934;30(1):44–48. doi:10.1001/archderm.1934.01460130052009