[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
August 1934


Arch Derm Syphilol. 1934;30(2):211-217. doi:10.1001/archderm.1934.01460140037006

The often bizarre neurologic symptoms and signs occurring in conjunction with nevoid changes in the skin are perhaps more familiar to the neurologist than to the dermatologist. In most cases, however, the recognition of the nature of the cutaneous changes gives the key to the diagnosis. Since the skin and the nervous system have a common embryonic origin, namely, the ectoderm, aberrations in the genesis of this embryonal layer often result in congenital malformations affecting both structures selectively. To this varied group of neurologic signs and symptoms, following no true pattern and occurring in association with cutaneous nevi, the term neurocutaneous syndrome has been applied. The wide variety of neural and cutaneous pictures included in this syndrome is to be expected, inasmuch as the nature and degree of aberration from the normal will depend on the stage of embryologic development and differentiation reached by the embryonic ectodermal layer when the