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Article
November 1934

ARSPHENAMINE DERMATITIS: ATTEMPTED SENSITIZATION TO NEOARSPHENAMINE AND FURTHER OBSERVATIONS ON THE PATCH TEST

Author Affiliations

DALLAS, TEXAS

From the Department of Dermatology and Syphilology, Baylor University,. School of Medicine.

Arch Derm Syphilol. 1934;30(5):672-675. doi:10.1001/archderm.1934.01460170064007
Abstract

Three years ago I published the results of the patch test in eight cases of postarsphenamine dermatitis. The conclusion of that study was that a positive patch test was an absolute contraindication to further arsphenamine therapy, but that a negative patch test permitted further administration of the arsphenamines. A résumé of the literature accompanied the communication.1

At that time it was thought that the patch test probably was the best method of determining cutaneous sensitization to the arsphenamines. The scratch test was thought to be unreliable, and the intradermal test was regarded as a procedure which might produce sensitivity to the drug. Moore, Woo, Robinson and Gay2 studied the intradermal test in different types of patients. Their results showed positive reactions in 60 per cent of normal persons, in 70 per cent of patients who had had arsphenamine dermatitis and in 94 per cent of patients with hay

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