It was a fortuitous anticipation that prompted a biospectrometric1 analysis in a typical case of psoriasis. The biopsy specimen was obtained from the central portion of a psoriatic lesion the size of a palm on the anterior aspect of the left leg (table 2, case 23). Since the normal metallic constituents of dermal biopsy specimens had been previously determined, the presence of a relatively large quantity of nickel in a psoriatic biopsy specimen was most significant.2 This report includes the various sources for nickel in human tissue, the incidence of nickel in apparently normal dermal biopsy specimens and the quantity of nickel found in psoriatic biopsy specimens.
While the economic importance of the known deposits of nickel ores in the earth's crust would seem to connote a comparative rarity of this metal, geochemistry has definitely established its universal distribution in soils, plants and animal life. The Danish naturalist
GAUL LE, STAUD AH. CLINICAL SPECTROSCOPY: THE QUANTITATIVE RETENTION OF NICKEL IN PSORIASIS; OBSERVATIONS ON FORTY-SIX CASES. Arch Derm Syphilol. 1934;30(5):697–703. doi:10.1001/archderm.1934.01460170089010
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