In view of the recent interest in granulocytopenia, agranulocytic angina or agranulocytosis—whatever term may be preferred—I report a case of acute pemphigus occurring in a patient with granulocytopenia.
The degenerative changes of the mucous membrane of the throat and mouth frequently seen in granulocytopenia were pronounced in this patient. The sloughing and lesions of the entire large intestine, stomach and esophagus, however, were more like those of acute pemphigus—just as the cutaneous condition was typical of the textbook description of acute pemphigus. The cutaneous lesions occasionally described in granulocytopenia are of a different type from those encountered in this case. The typical granulocytopenic lesions seem to be seated more deeply in the skin, usually with necrotic areas and crusts covering them and with definite enlargement of the regional lymph nodes. However, I have not been able to find any references in the literature to acute pemphigus occurring in patients with
FIALA MJ. ACUTE PEMPHIGUS: REPORT OF CASE OCCURRING IN GRANULOCYTOPENIA. Arch Derm Syphilol. 1934;30(5):704–705. doi:10.1001/archderm.1934.01460170096011
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