The value of the Frei test in the diagnosis of lymphogranuloma inguinale is now generally recognized. Little is known, however, about the substance that is responsible for the reaction. The work reported here has been undertaken in order to ascertain the extent to which the properties of the original fresh pus derived from uncontaminated inguinal buboes are preserved or modified by drying in vacuo from the frozen state. The ability to withstand drying of the agent responsible for the production of a positive Frei reaction has not, to our knowledge, been investigated.
This article deals with the comparison of the cutaneous reactions produced in normal subjects and in patients with recent and old cases of lymphogranuloma inguinale by the use of Frei antigens of various strengths prepared from fresh and dried pus. The titer of such antigens was established at the same time in the same persons.
There was no
GRACE AW, Suskind FH. LYMPHOGRANULOMA INGUINALE: I. PRESERVATION OF FREI ANTIGEN BY DRYING; ITS CONCENTRATION IN FRESH AND IN DRIED PUS. Arch Derm Syphilol. 1934;30(6):823–830. doi:https://doi.org/10.1001/archderm.1934.01460180065010
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