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To the Editor.—
I am reporting the following case because of its unusual features:About eight months ago, there was referred to me S. G., a college chemistry instructor, who presented a typical giant urticaria, with all of its distressing symptoms. The history was that about five days previous, out of a clear sky, the giant wheals had appeared, and they had been present almost constantly since then. The man's occupation immediately suggested a possible chemical etiology, although other causes were not ignored. The man was rather heavy, weighing about 230 pounds, (104 Kg.), and was about 66 inches (167 cm.) tall. The family and past histories were irrelevant.Tbe patient was questioned carefully as to contacts, and intradermal and patch tests were performed, all of which took considerable time. During this period the condition in no way improved, the only relief being that given by local applications which acted