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The occurrence of lymphogranuloma inguinale and the group of diseases caused by the same virus are no longer a rarity in China. With the aid of Frei's reaction one has no difficulty in diagnosis. Characteristic histologic changes have also been observed. Although I have nothing to say against the reliability of Frei's reaction, in a few instances I have met with difficulties in obtaining and preparing the antigen and in occasional instances I have observed failure of the antigen. The antigenic property was sometimes missing in the pus of a person with a clinically evident case, a fact which has also been confirmed by Nicolau and Bancini.
It was therefore my endeavor to find a method which would replace or complement the Frei test.
Gottlieb spoke of the action of the serum of patients convalescing from lymphogranuloma. I have tried to reexamine this problem from another point of view. I
REISS F. A NEW IMMUNOLOGIC REACTION FOR THE DIAGNOSIS OF LYMPHOGRANULOMA INGUINALE: PRELIMINARY REPORT. Arch Derm Syphilol. 1935;31(2):215–216. doi:10.1001/archderm.1935.01460200059006
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